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LR-17

CAT: 0804-HY-P11077-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P11077-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LR-17 (TLT-1 (94-110) ), a 17-aa peptide, is a TREM-1 inhibitor. LR-17 shows anti-inflammatory effects that can reduce the secretion of pro-inflammatory cytokines induced by Lipopolysaccharides (LPS). LR-17 can be used for the study of sepsis[1].
CAS Number
1256099-50-9
Product Name Alternative
TLT-1 (94-110)
UNSPSC
12352209
Target
TREM receptor
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
97.52
Smiles
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CS)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C74H115N21O30S2
Molecular Weight
1842.96
References & Citations
[1]Siskind S, et al. TREM-1 Modulation Strategies for Sepsis. Front Immunol. 2022 Jun 15;13:907387. doi: 10.3389/fimmu.2022.907387.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Leu-Gln-Glu-Glu-Asp-Ala-Gly-Glu-Tyr-Gly-Cys-Met-Val-Asp-Gly-Ala-Arg-OH
CAS Number1256099-50-9
PubChem CID178203515
IUPAC Name(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[2-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC74H115N21O30S2
Molecular Weight1843.0
XLogP-9.4
Topological Polar Surface Area867
Hydrogen Bond Donor Count29
Hydrogen Bond Acceptor Count34
Rotatable Bond Count63
Heavy Atom Count127
Formal Charge0
Complexity3890
SMILES
C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)N
InChI
InChI=1S/C74H115N21O30S2/c1-33(2)25-39(75)62(113)87-41(14-18-50(76)97)66(117)88-42(16-20-55(103)104)67(118)89-43(17-21-56(105)106)68(119)93-48(28-58(109)110)70(121)84-35(5)60(111)80-30-52(99)85-40(15-19-54(101)102)65(116)92-46(26-37-10-12-38(96)13-11-37)63(114)82-31-53(100)86-49(32-126)71(122)90-44(22-24-127-7)69(120)95-59(34(3)4)72(123)94-47(27-57(107)108)64(115)81-29-51(98)83-36(6)61(112)91-45(73(124)125)9-8-23-79-74(77)78/h10-13,33-36,39-49,59,96,126H,8-9,14-32,75H2,1-7H3,(H2,76,97)(H,80,111)(H,81,115)(H,82,114)(H,83,98)(H,84,121)(H,85,99)(H,86,100)(H,87,113)(H,88,117)(H,89,118)(H,90,122)(H,91,112)(H,92,116)(H,93,119)(H,94,123)(H,95,120)(H,101,102)(H,103,104)(H,105,106)(H,107,108)(H,109,110)(H,124,125)(H4,77,78,79)/t35-,36-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,59-/m0/s1
InChIKey
HACSRWIJGRNYLK-RMBIPVDZSA-N
Chemical Structure
2D Structure
2D structure of H-Leu-Gln-Glu-Glu-Asp-Ala-Gly-Glu-Tyr-Gly-Cys-Met-Val-Asp-Gly-Ala-Arg-OH
CAS: 1256099-50-9
CID: 178203515
Formula: C74H115N21O30S2
MW: 1843.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1843.0
XLogP3-9.4
Hydrogen Bond Donor Count29
Hydrogen Bond Acceptor Count34
Rotatable Bond Count63
Exact Mass1841.7560137
Monoisotopic Mass1841.7560137
Topological Polar Surface Area867 Ų
Heavy Atom Count127
Formal Charge0
Complexity3890
Isotope Atom Count0
Defined Atom Stereocenter Count14
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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