Microcystin-LR

• UNSPSC Description:

  Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.

• Target Antigen:

  Phosphatase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.0

• Solubility:

  Ethanol : 0.5 mg/mL (ultrasonic)

• Smiles:

  CC(/C=C/[C@@H]([C@@H](C(N[C@H](CCC(N(C(C(N[C@@H]1C)=O)=C)C)=O)C(O)=O)=O)C)NC([C@@H](NC([C@H]([C@@H](NC([C@](NC1=O)([H])CC(C)C)=O)C(O)=O)C)=O)CCCNC(N)=N)=O)=C\[C@H](C)[C@@H](OC)CC2=CC=CC=C2

• Molecular Weight:

  995.17

• References & Citations:

  [1]Honkanen RE, et al. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem. 1990 Nov 15;265(32):19401-4.|[2]Lone Y, et al. Microcystin-LR Induced Immunotoxicity in Mammals. J Toxicol. 2016:8048125.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  101043-37-2