D-KLA Peptide-d30

CAT: 0804-HY-P10285SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10285SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-KLA Peptide-d30 (D- (KLAKLAK) 2-d30) is the deuterium labeled d-KLA Peptide (HY-P10285) . d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase) . d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects[1][2].
Product Name Alternative
D- (KLAKLAK) 2-d30
UNSPSC
12352209
Target
Caspase; Isotope-Labeled Compounds; Mitochondrial Metabolism; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCCCC[C@H](C(NC(C(N[C@@H](C(N[C@@H](C(NC(C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NC(C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CCCCN)C(O)=O)=O)C)=O)CC(C)C)=O)CCCCN)=O)C)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)CCCCN)=O)CCCCN)=O)C)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)CCCCN)=O)C)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)N
Molecular Formula
C72H108D30N20O15
Molecular Weight
1554.18
References & Citations
[1]Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32 (22) : 5262-5268.|[2]Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D- (KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6 (3) : 971-977.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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