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D-KLA Peptide

CAT: 0804-HY-P10285-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10285-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase) . d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects[1][2].
CAS Number
286380-05-0
Product Name Alternative
D- (KLAKLAK) 2
UNSPSC
12352209
Target
Caspase; Mitochondrial Metabolism; PARP
Type
Peptides
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-kla-peptide.html
Purity
99.33
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](N)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C72H138N20O15
Molecular Weight
1523.99
References & Citations
[1]Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32 (22) : 5262-5268.|[2]Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D- (KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6 (3) : 971-977.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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