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D-T101 peptide

CAT: 0804-HY-P11298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P11298Size:1 Each
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Description
D-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site[1][2][3].
CAS Number
2120397-85-3
UNSPSC
12352209
Target
Apoptosis; Caspase; IFNAR; Interleukin Related; JNK; p38 MAPK
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
NCCCC[C@H](C(O)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCC(O)=O)NC([C@H](NC([C@@H](CC(C)C)NC([C@@H]([C@@H](O)C)NC([C@@H](CO)NC([C@@H]1N(CCC1)C([C@@H](CC(C)C)NC([C@H](NC([C@H](NC([C@@H]([C@@H](O)C)NC([C@H](NC([C@H](N)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)CC8=CNC9=CC=CC=C89)=O)=O)=O
Molecular Formula
C96H129N21O20
Molecular Weight
1897.18
References & Citations
[1]Sandler U, et al. NEROFE--a novel human hormone-peptide with anti-cancer activity. J Exp Ther Oncol. 2010;8 (4) :327-39. |[2]Ohana J, et al. dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function. Mol Clin Oncol. 2017 Dec;7 (6) :991-999. |[3]Ohana J, et al. Transformation of immunosuppressive mtKRAS tumors into immunostimulatory tumors by Nerofe and Doxorubicin. Oncotarget. 2023 Jul 1;14:688-699.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9; IL-2

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