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Catenarin

CAT: 0804-HY-N11723Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N11723Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
CAS Number
476-46-0
Product Name Alternative
Katenarin
UNSPSC
12352005
Target
Calcium Channel; CCR; CXCR; JNK; p38 MAPK
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C2=C(C(C3=C(C=C(C)C(O)=C13)O)=O)C(O)=CC(O)=C2
Molecular Formula
C15H10O6
Molecular Weight
286.24
References & Citations
[1]Shen MY, et al. Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways. Evid Based Complement Alternat Med. 2012;2012:982396. |[2]Anke H, et al. The anthraquinones of the Aspergillus glaucus group. I. Occurrence, isolation, identification and antimicrobial activity. Arch Microbiol. 1980 Jul;126 (3) :223-30.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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GTR19242885-01Catenarin

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