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Centaureidin

CAT: 0804-HY-N10341Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10341Size:1 Each
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Description
Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice[1][2][3][4][5].
CAS Number
17313-52-9
UNSPSC
12352005
Target
IFNAR; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C(OC)=C(C2=CC(O)=C(OC)C=C2)OC3=CC(O)=C(C(O)=C13)OC
Molecular Formula
C18H16O8
Molecular Weight
360.31
References & Citations
[1]Chang SL, et al. Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. J Ethnopharmacol. 2007 Jun 13;112 (2) :232-6. |[2]Ito Y, et al. Centaureidin promotes dendrite retraction of melanocytes by activating Rho. Biochim Biophys Acta. 2006 Mar;1760 (3) :487-94. |[3]Csupor-Löffler B, et al. Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother Res. 2009 May;23 (5) :672-6. |[4]Orallo F, et al. Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis. Planta Med. 1998 Mar;64 (2) :116-9. |[5]Abad M.J., et al. Anti-inflammatory activity of two flavonoids from Tanacetum microphyllum. J Nat Prod. 1993 Jul;56 (7) :1164-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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