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β-catenin-IN-8

CAT: 0804-HY-169348Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169348Size:1 Each
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Description
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4) . β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability[1].
CAS Number
259130-14-8
UNSPSC
12352005
Target
C-Myc; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-in-8.html
Smiles
O=S(C1=CC=C(Cl)C=C1)(NC2=CC=C(N3C=CN=C3)C=C2)=O
Molecular Formula
C15H12ClN3O2S
Molecular Weight
333.79
References & Citations
[1]Puxeddu M, et al. Development of N- (4- (1H-Imidazol-1-yl) phenyl) -4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability. J Med Chem. 2024 Nov 28;67 (22) :20298-20314.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-chloro-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
CAS Number259130-14-8
PubChem CID110867679
IUPAC Name4-chloro-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
Molecular FormulaC15H12ClN3O2S
Molecular Weight333.8
XLogP2.8
Topological Polar Surface Area72.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity452
SMILES
C1=CC(=CC=C1NS(=O)(=O)C2=CC=C(C=C2)Cl)N3C=CN=C3
InChI
InChI=1S/C15H12ClN3O2S/c16-12-1-7-15(8-2-12)22(20,21)18-13-3-5-14(6-4-13)19-10-9-17-11-19/h1-11,18H
InChIKey
KIQPGVHAKJPRNX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-chloro-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
CAS: 259130-14-8
CID: 110867679
Formula: C15H12ClN3O2S
MW: 333.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight333.8
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass333.0338755
Monoisotopic Mass333.0338755
Topological Polar Surface Area72.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T201581-01β-catenin-IN-8
T205083-01β-Catenin modulator-8
BUP22129-01SS-Catenin modulator-8
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SIPB010Hu02-01Recombinant Beta Catenin (β-catenin)
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