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CFDA-SE (solution)

CAT: 0804-HY-DY1009Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0804-HY-DY1009Size:100 µL
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Description
CFDA-SE (solution) is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus[1]. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells[1].Solvent and concentration: DMSO: 5 mM
CAS Number
150347-59-4
Target
Fluorescent Dye
Related Pathways
Others
Field of Research
Others
Smiles
CC(OC1=CC=C(C2(C(C=CC(C(ON3C(CCC3=O)=O)=O)=C4)=C4C(O2)=O)C(C=CC(OC(C)=O)=C5)=C5O6)C6=C1)=O.CC(OC7=CC=C(C8(C(C=C(C(ON9C(CCC9=O)=O)=O)C=C%10)=C%10C(O8)=O)C(C=CC(OC(C)=O)=C%11)=C%11O%12)C%12=C7)=O
Molecular Formula
C58H38N2O22
Molecular Weight
1114.93
References & Citations
[1]Banks HT, et al. Quantifying CFSE Label Decay in Flow Cytometry Data. Appl Math Lett. 2013 May 1;26 (5) :571-577.|[2]Cui J, et al. Prostaglandin E3 attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization. J Cell Mol Med. 2021 Jun;25 (12) :5586-5601.|[3]A Bruce Lyons, et al. Flow cytometric analysis of cell division by dilution of CFSE and related dyes. Curr Protoc Cytom. 2013; Chapter 9:Unit9.11.|[4]Xiuyun Jiang et al. Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment. Oncoimmunology. 2017; 6 (7) : e1333210.
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20°C for 1 year, protect from light. Avoid repeated freezing and thawing
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

5(6)-Carboxyfluorescein diacetate succinimidyl ester

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CAS Number150347-59-4
PubChem CID16211581
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 3',6'-diacetyloxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate;(2,5-dioxopyrrolidin-1-yl) 3',6'-diacetyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylate
Molecular FormulaC58H38N2O22
Molecular Weight1114.9
Topological Polar Surface Area304
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count22
Rotatable Bond Count14
Heavy Atom Count82
Formal Charge0
Complexity2190
SMILES
CC(=O)OC1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)C(=O)ON5C(=O)CCC5=O)C(=O)O3)C6=C(O2)C=C(C=C6)OC(=O)C.CC(=O)OC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)OC(=O)C)C5=C(C=CC(=C5)C(=O)ON6C(=O)CCC6=O)C(=O)O3
InChI
InChI=1S/2C29H19NO11/c1-14(31)37-17-4-7-21-23(12-17)39-24-13-18(38-15(2)32)5-8-22(24)29(21)20-6-3-16(11-19(20)28(36)40-29)27(35)41-30-25(33)9-10-26(30)34;1-14(31)37-17-4-7-20-23(12-17)39-24-13-18(38-15(2)32)5-8-21(24)29(20)22-11-16(3-6-19(22)28(36)40-29)27(35)41-30-25(33)9-10-26(30)34/h2*3-8,11-13H,9-10H2,1-2H3
InChIKey
LZFDYQHOQDFMOA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5(6)-Carboxyfluorescein diacetate succinimidyl ester
CAS: 150347-59-4
CID: 16211581
Formula: C58H38N2O22
MW: 1114.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1114.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count22
Rotatable Bond Count14
Exact Mass1114.19162084
Monoisotopic Mass1114.19162084
Topological Polar Surface Area304 Ų
Heavy Atom Count82
Formal Charge0
Complexity2190
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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