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ML-10

CAT: 0804-HY-76573-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-76573-01Size:5 mg
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Description
ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].
CAS Number
1216897-16-3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer; Cardiovascular Disease
Purity
95.0
Smiles
O=C(O)C(C)(CCCCCF)C(O)=O
Molecular Formula
C9H15FO4
Molecular Weight
206.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19 (5) :625-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

ML-10
CAS Number1216897-16-3
PubChem CID57514438
IUPAC Name2-(5-fluoropentyl)-2-methylpropanedioic acid
Molecular FormulaC9H15FO4
Molecular Weight206.21
XLogP1.8
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count14
Formal Charge0
Complexity201
SMILES
CC(CCCCCF)(C(=O)O)C(=O)O
InChI
InChI=1S/C9H15FO4/c1-9(7(11)12,8(13)14)5-3-2-4-6-10/h2-6H2,1H3,(H,11,12)(H,13,14)
InChIKey
BOYGOAXVKOOCKN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ML-10
CAS: 1216897-16-3
CID: 57514438
Formula: C9H15FO4
MW: 206.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight206.21
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass206.09543712
Monoisotopic Mass206.09543712
Topological Polar Surface Area74.6 Ų
Heavy Atom Count14
Formal Charge0
Complexity201
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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