Products for Research Use Only
RegisterLogin

ML-T7

CAT: 0804-HY-163028-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163028-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab. ML-T7 can be used for tumor immunotherapy research[1].
CAS Number
459789-75-4
UNSPSC
12352005
Target
Tim3
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml-t7.html
Purity
99.93
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(C13OC(C4C(N(C5=CC=C(C=C5Cl)Cl)C(C43)=O)=O)C6=CC=C(C)C=C6)=O)C=CC=C2
Molecular Formula
C27H17Cl2NO5
Molecular Weight
506.33
References & Citations
[1]Ma S, et al. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci Transl Med. 2023 Nov 15;15 (722) :eadg6752.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P10323T7 Peptide
HY-P10323A-01T7 Peptide (TFA)
HY-172724DSPE-PEG5000-T7
HY-KE8005T7 Endonuclease I
HY-172723-01DSPE-PEG2000-T7
HY-172722DSPE-PEG1000-T7
HY-P0327-01T7 Tag Peptide
HY-172723ADSPE-PEG3400-T7
HY-E70090-01T7 RNA polymerase
HY-P70950-01IGF2BP2, Human (T7-His)

Alternative Products

CatalogName
T86911-01ML-T7
8119/50ML T7
EZ0025T7 Polymerase (50,000 U/ml)
TD-BP029741T7
PVT83150T7-6xHis-GNAQ-T7-RIC8A Plasmid
TP790220T7 Escherichia phage T7 Recombinant Protein
P106000PETDuet-T7-6xHis-MCS-T7-EGFP
P5479T7-Tpase
GWB-3A5F70T7 Antibody
046308T7-Tag

Popular Products