ML-10

• Description :

  ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer; Cardiovascular Disease

• Purity :

  95.0

• Smiles :

  O=C(O)C(C)(CCCCCF)C(O)=O

• Molecular Formula :

  C9H15FO4

• Molecular Weight :

  206.21

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19 (5) :625-37.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1216897-16-3]