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(1S,9R) -Ac-Exatecan

CAT: 0804-HY-43565CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-43565CSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(1S,9R) -Ac-Exatecan is an intermediate for the synthesis of Exatecan. Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).
UNSPSC
12352005
Target
Drug Intermediate
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
References & Citations
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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