IITZ-01

• UNSPSC Description:

  IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.

• Target Antigen:

  Apoptosis; Autophagy; PI3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IITZ-01.html

• Purity:

  98.18

• Solubility:

  DMSO : 150 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C(NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=CC=CC=C6N5)C=C4)=N2)C=C1

• Molecular Weight:

  482.51

• References & Citations:

  [1]Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2018 Aug 30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1807988-47-1