MK-2748

• Description:

  MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM) . MK-2748 can be used in the research of HCV infection[1].

• UNSPSC:

  12352005

• Target:

  HCV; HCV Protease

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Smiles:

  O=C([C@H](C[C@](OC(N1CCCCC[C@@]2([H])[C@](CCC2)([H])O3)=NC4=CC(OC)=CC=C4C1=O)([H])C5)N5C([C@H](C6CCCC6)NC3=O)=O)N[C@]7([C@H](C=C)C7)C(NS(=O)(C8(CC8)C)=O)=O

• Molecular Formula:

  C42H56N6O10S

• Molecular Weight:

  836.99

• References & Citations:

  [1]Rudd MT, et al. P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325. ChemMedChem. 2015 Apr;10 (4) :727-35.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1193902-95-2]