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MK-2748

CAT: 0804-HY-19932Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19932Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM) . MK-2748 can be used in the research of HCV infection[1].
CAS Number
[1193902-95-2]
UNSPSC
12352005
Target
HCV; HCV Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C([C@H](C[C@](OC(N1CCCCC[C@@]2([H])[C@](CCC2)([H])O3)=NC4=CC(OC)=CC=C4C1=O)([H])C5)N5C([C@H](C6CCCC6)NC3=O)=O)N[C@]7([C@H](C=C)C7)C(NS(=O)(C8(CC8)C)=O)=O
Molecular Formula
C42H56N6O10S
Molecular Weight
836.99
References & Citations
[1]Rudd MT, et al. P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325. ChemMedChem. 2015 Apr;10 (4) :727-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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