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UK-371800

CAT: 0804-HY-19446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19446Size:1 Each
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Description
UK-371800 is a highly selective PDE5 inhibitor (IC50 = 4.2 nM) . UK-371800 has good permeability and is not affected by the efflux of P-glycoprotein[1].
CAS Number
247582-13-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
O=C1C2=NN(C)C(CC)=C2NC(C3=CC(S(=O)(N4CCN(CC)CC4)=O)=CN=C3O[C@H](C)COC)=N1
Molecular Formula
C23H33N7O5S
Molecular Weight
519.62
References & Citations
[1]Bunnage ME, et al. Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett. 2008 Dec 1;18 (23) :6033-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PDE5

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