Ro-65-2299

CAT: 0804-HY-19380Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-19380Size:1 Each

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Description

Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM) . Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg) . Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis[1].

CAS Number

241151-12-2

UNSPSC

12352211

Target

Drug Derivative; VD/VDR

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

O[C@H]1C[C@H](O)C/C(C1)=C/C=C/CCCC(C)(C)C/C=C\C(C(F)(F)F)(O)C(F)(F)F

Molecular Formula

C21H30F6O3

Molecular Weight

444.45

References & Citations

[1]Bolla NR, et al. Retiferols-synthesis and biological activity of a conceptually novel class of vitamin D analogs. Expert Opin Ther Pat. 2014 Jun;24 (6) :633-46.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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