RO 4938581

• Description:

  RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively) ; RO 4938581 is used in the research of cognitive dysfunction.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/RO_4938581.html

• Purity:

  99.78

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F

• Molecular Formula:

  C13H8BrF2N5

• Molecular Weight:

  352.14

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19 (20) :5940-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [883093-10-5]