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FK-788

CAT: 0804-HY-19255Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19255Size:1 Each
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Description
FK-788 is a PGI (2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM[1][2].
CAS Number
227951-89-5
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Others
Smiles
O=C(O)COC1=C2CC[C@](O)(COC(N(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC2=CC=C1
Molecular Formula
C26H25NO6
Molecular Weight
447.48
References & Citations
[1]Kouji Hattori, et al. Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett. 2005 Jun 15;15 (12) :3091-5.|[2]Fujiko Takamura, et al. Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5. Bioorg Med Chem Lett. 2006 Sep 1;16 (17) :4475-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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