FK 409

• Description:

  FK 409 is a NO donor that can penetrate cell membranes. FK 409 has a vasodilatory effect on bovine retinal arteries. FK 409 alleviates acute-phase inflammation, induces HSP, and mitigates liver transplantation injury in a rat model of orthotopic liver transplantation. FK 409 can be used in research on cardiovascular diseases and liver transplant rejection and inflammatory immune system disorders[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  HSP; NO Synthase

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Smiles:

  CC([N+]([O-])=O)/C(CC)=C/C(C(N)=O)=N/O

• Molecular Formula:

  C8H13N3O4

• Molecular Weight:

  215.21

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Man K, et al. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg. 2004 Jul;240 (1) :159-68.|[2]Sugimoto K, et al. [Vasodilatory action of FK 409 on bovine retinal arteries--analysis by a microvessel perfusion system]. Nippon Ganka Gakkai Zasshi. 2002 Jun;106 (6) :338-42. Japanese.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  Phase 2

• CAS Number:

  92454-60-9