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FK-3000

CAT: 0804-HY-N11097Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N11097Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1[1][2][3][4].
CAS Number
1054312-81-0
UNSPSC
12352005
Target
Apoptosis; HIV; HSV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/fk-3000.html
Solubility
10 mM in DMSO
Smiles
COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4OC(C)=O)C[C@H](OC(C)=O)[C@@H]1O
Molecular Formula
C22H27NO7
Molecular Weight
417.45
References & Citations
[1]Xu HD, et, al. FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol. 2015;46 (6) :2309-16. |[2]Li YC, et, al. 6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation. Int J Oncol. 2015 Feb;46 (2) :578-86. |[3]Nawawi A, et, al. In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1. Phytother Res. 2001 Sep;15 (6) :497-500. |[4]Lee JH, et, al. Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development. J Pharm Biomed Anal. 2012 Nov;70:587-91.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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