FK 633

• Description :

  FK 633 (FR-144633) is a fibrinogen inhibitor and peptide mimetic GPIIbIIa receptor antagonist. FK 633 has anti-platelet and anti-thrombotic effects. FK 633 inhibits ADP-, collagen-, thrombin-, and PAF-induced platelet aggregation with IC50 values of 103, 87, 98, and 239 nM, respectively[1][2].

• Product Name Alternative :

  FR-144633

• UNSPSC :

  12352005

• Target :

  Integrin; Thrombin

• Related Pathways :

  Cytoskeleton; Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Smiles :

  CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(CCCOC1=CC=C(C(N)=N)C=C1)=O)=O

• Molecular Formula :

  C20H28N4O7

• Molecular Weight :

  436.46

• References & Citations :

  [1]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50. |[2]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [147865-49-4]