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BQ-788

CAT: 0804-HY-15894A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15894A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM[1].
CAS Number
173326-37-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/BQ-788.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC[C@H](C(O)=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O
Molecular Formula
C34H51N5O7
Molecular Weight
641.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Okada M, et al. BQ-788, a selective endothelin ET (B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20 (1) :53-66.|[2]Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.|[3]Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
ETB
Citation 01
Cells. 2021 Nov 8;10 (11) :3072.|Environ Pollut. 2016 Feb:209:11-20.|Environ Pollut. 2016 Nov:218:487-496.|J Exp Clin Cancer Res. 2025 Feb 21;44 (1) :64.|Neurotherapeutics. 2021 Oct;18 (4) :2664-2681.|Toxicol Sci. 2016 Jan;149 (1) :213-26.|BMC Cancer. 2018 Feb 6;18 (1) :154.|Environ Sci Pollut Res Int. 2018 May;25 (15) :14713-14725.|J Neuroimmune Pharmacol. 2024 Apr 13;19 (1) :13.|PLoS Pathog. 2020 Oct 19;16 (10) :e1008947.

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