CI-990

• Description :

  CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis) [1][2].

• Product Name Alternative :

  PD-131112

• UNSPSC :

  12352005

• Target :

  Bacterial; DNA/RNA Synthesis

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research :

  Infection

• Smiles :

  O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@@H](NC([C@@H](N)C)=O)CC4)=N3)C1=O)O

• Molecular Formula :

  C19H22FN5O4

• Molecular Weight :

  403.41

• References & Citations :

  [1]Cohen MA, et al. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J Antimicrob Chemother. 1998 Jun;41 (6) :605-14.|[2]Cohen MA, et al. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995 Sep;39 (9) :2123-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [122536-20-3]