CI-990

• Description:

  CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis) [1][2].

• Product Name Alternative:

  PD-131112

• UNSPSC:

  12352005

• Target:

  Bacterial; DNA/RNA Synthesis

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research:

  Infection

• Smiles:

  O=C (C1=CN (C2CC2) C3=C (C=C (F) C (N4C[C@@H] (NC ([C@@H] (N) C) =O) CC4) =N3) C1=O) O

• Molecular Formula:

  C19H22FN5O4

• Molecular Weight:

  403.41

• References & Citations:

  [1]Cohen MA, et al. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J Antimicrob Chemother. 1998 Jun;41 (6) :605-14.|[2]Cohen MA, et al. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995 Sep;39 (9) :2123-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  122536-20-3