CI-949

• Description:

  CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

• UNSPSC:

  12352005

• Target:

  Histamine Receptor; Leukotriene Receptor; Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/1H-Indole-2-carboxamide,_5-methoxy-3-_1-methylethoxy_-1-phenyl-N-2H-tetrazol-5-yl-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N1C2=CC=CC=C2)=C(OC(C)C)C3=C1C=CC(OC)=C3)NC4=NN=NN4

• Molecular Formula:

  C20H20N6O3

• Molecular Weight:

  392.41

• References & Citations:

  [1]Conroy MC, et al. Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86 (6 Pt 1) :902-8.|[2]Adolphson RL, et al. CI-949: a new, potential antiallergy compound inhibits antigen-induced allergic reactions in guinea-pigs in vitro and in vivo. Pulm Pharmacol. 1990;3 (4) :203-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  LTC4/CysLT2; LTD4/CysLT1; TXB2

• CAS Number:

  104961-19-5