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CGAS-IN-7

CAT: 0804-HY-179624Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179624Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGAS-IN-7 is a cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 0.66 μM for human cGAS. cGAS-IN-7 modestly decreases cGAMP levels in THP1 cells. cGAS-IN-7 can be used for the research of Alzheimer's disease[1].
UNSPSC
12352101
Target
Cyclic GMP-AMP Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
O=C(NS(=O)(C1=CC=C(OCC)C(Br)=C1)=O)CC2=CC=C(I)C=C2
Molecular Formula
C16H15BrINO4S
Molecular Weight
524.17
References & Citations
[1]Alarcón-Espósito J, et al. High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor. ACS Chem Biol. 2025;20 (12) :2886-2896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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