CGAS-IN-4

CAT: 0931-T204612-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204612-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2987886-49-5

Target

CGAS

Related Pathways

Immunology/Inflammation

Bioactivity

CGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS) . In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.

Smiles

C[C@H]1C=2C=3C(NC2CCN1C(=O)C=4N=CC(OCCO)=CN4)=C(Cl)C(Cl)=CC3

Molecular Formula

C19H18Cl2N4O3

Molecular Weight

421.277

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-170362-01	CGAS-IN-4
HY-170362A-01	(R) -cGAS-IN-4
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CGAS-IN-4

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