CGAS-IN-4

CAT: 0804-HY-170362-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-170362-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149) -induced acute liver injury in mouse models[1]. orally active, THP-1, C57Bl/6 mouse, orally active
CAS Number
[2987886-49-5]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H]1C(C2=CC=C3Cl)=C(CCN1C(C4=NC=C(OCCO)C=N4)=O)NC2=C3Cl
Molecular Formula
C19H18Cl2N4O3
Molecular Weight
421.28
References & Citations
[1]Cyr P, et al., Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization. ACS Med Chem Lett. 2024 Nov 25;15 (12) :2201-2209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-162459CGAS-IN-3
HY-160546-01CGAS-IN-2
HY-179147CGAS-IN-6
HY-P703401-01CGAS, MOUSE
HY-179624CGAS-IN-7
HY-149526-01CGAS-IN-1
HY-P703402-01CGAS, MOUSE (Biotinylated)
HY-P72337-01CGAS, Human (His)
HY-P86195-01CGAS Antibody (YA5887, Rabbit)
HY-172208-01PROTAC cGAS degrader-1

Alternative Products

CatalogName
MF-0113119-01CGAS-IN-4
MF-0008674-01(R) -cGAS-IN-4
YP-W69479-01Chicken cGAS (cGAS) ELISA Kit
E51A08095CGAS Antibody
BA5952-5cGAS-IN-1
BA5951-10cGAS-IN-2
PPL01404-1aPET28a (+) -CGAS
MF-0117237-01CGAS-IN-3
A20342CGAS Rabbit pAb
ANT-11478-100ugCGAS Polyclonal Antibody

Popular Products