KRAS-IN-43

CAT: 0804-HY-176250Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176250Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
KRAS-IN-43 (Compound 9) is a pan-KRAS inhibitor with IC50 values of 0.15 μM, 0.14 μM, and 0.47 μM against KRASG12V, KRASG12C and wild-type KRAS, respectively. KRAS-IN-43 disrupts the interaction between KRAS and cRAF, and inhibits ERK phosphorylation. KRAS-IN-43 is promising for research of KRAS mutation-related cancers (such as pancreatic cancer, colorectal cancer, and lung cancer) [1].
UNSPSC
12352005
Target
ERK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
C#CC1=C(C=CC2=CC(O)=CC(C(N3CCC4=C(C3)C=CC=C4OCC56CCCN5CCC6)=O)=C21)F
Molecular Formula
C30H29FN2O3
Molecular Weight
484.56
References & Citations
[1]Aladinskiy V, et al. Identification of Novel pan-KRAS Inhibitors via Structure-Based Drug Design, Scaffold Hopping, and Biological Evaluation[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

Related Products

CatalogName
HY-142945KRAS G12C inhibitor 43
HY-178501KRAS-IN-45
HY-176870KRAS-IN-42
HY-173329KRAS-IN-41
HY-179536KRAS-IN-49
HY-179300AKRAS-IN-48
HY-174379KRAS IN-44
HY-174261KRAS-IN-5
HY-178502KRAS-IN-46
HY-179253KRAS-IN-47

Alternative Products

CatalogName
MF-0117914-01KRAS-IN-43
MF-0142237-01KRAS G12C inhibitor 43
abx137610-01GTPase KRas (KRAS) Antibody
401665-01KRAS
CSB-EP012493HU-01Recombinant Human GTPase KRas (KRAS)
abx449534GTPase KRas (KRAS) Antibody (APC)
MBS962596-01Recombinant Rat GTPase KRas (Kras)
abx317303-01GTPase KRas (KRAS) Antibody (HRP)
abx449526GTPase KRas (KRAS) Antibody (ATTO488)

Popular Products