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KRAS-IN-5

CAT: 0804-HY-174261Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174261Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRAS-IN-5 (Compound Ex 6) is an orally active and selective inhibitor targeting KRAS mutants (including KRASG12D, KRASG12V, KRASWT) with a GNE IC50 value of 1.3 nM against KRASG12D. KRAS-IN-5 blocks tumor cell proliferation by inhibiting KRAS-mediated signaling pathways (e.g., reducing ERK phosphorylation) . KRAS-IN-5 is promising for research of KRAS mutation-related cancers, such as pancreatic cancer, colorectal cancer, lung cancer[1].
CAS Number
[3082412-00-5]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
FC1=C(CC)C2=C(C=C(NN=C3C)C3=C2C4=C(F)C(N=C(OC[C@@]56CCCN5C[C@H](F)C6)N=C7N(CCCOC8)[C@@H]8CO9)=C7C9=N4)C=C1
Molecular Formula
C35H36F3N7O3
Molecular Weight
659.70
References & Citations
[1]Shuhei Kawamura, et al. Small molecule inhibitors of kras proteins. WO2025085748A1. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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