PDE2-IN-1

• Description :

  PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 μM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA) -induced Alzheimer’s disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE) ; PKA

• Related Pathways :

  Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  O=C1C2=NN(CCO)C(C(NC(C3=CC=C(C(F)(F)F)C=C3)C)=O)=C2CCN1

• Molecular Formula :

  C18H19F3N4O3

• Molecular Weight :

  396.36

• References & Citations :

  [1]Yang F, et al. Discovery of novel 2,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridine-7-one derivatives as PDE2 inhibitors with Alzheimer's disease therapeutic potential. Eur J Med Chem. 2026;302 (Pt 1) :118302.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE2