PDE5/HDAC-IN-1

PDE5/HDAC-IN-1

• CAS Number: 2414921-48-3
• UNSPSC Description: PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1].
• Target Antigen: Apoptosis; HDAC; Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pde5-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N2[C@@](C3=CC=C(C=C3)Br)([H])C4=C(C[C@]2([H])C(N(C1)CCCCCCC(NO)=O)=O)C5=CC=CC=C5N4
• Molecular Weight: 553.45
• References & Citations: [1]ElHady AK, et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported