PDE12-IN-1
CAT:
804-HY-117318-05
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PDE12-IN-1
- CAS Number: 2259620-80-7
- UNSPSC Description: PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1].
- Target Antigen: Phosphodiesterase (PDE)
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/pde12-in-1.html
- Purity: 98.85
- Solubility: DMSO : 90 mg/mL (ultrasonic)
- Smiles: N#CC1=CC2=C(C=C1)C(C3=NC4=CC(Br)=C(C(N5[C@H](CO)[C@@H](C6=CC=C(F)C=C6)OCC5)=O)C=C4N3C)=CN2CC
- Molecular Weight: 616.48
- References & Citations: [1]Wood ER, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290(32):19681-96.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported