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KRAS-IN-48 free base

CAT: 0013-GTR19274812-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274812-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRAS-IN-48 free base (Compound 1-01) is a mutant KRAS inhibitor with a Kd value of 2.58 nM for KRAS G12D and 5.49 μM for KRAS G12V. It affects pERK expression in cells harboring KRAS G12D and KRAS G12V mutations, with IC50 values of 1.1 μM and 1.51 μM respectively. This compound is applicable in cancer research.
CAS Number
3074833-86-3
Smiles
O (C=1N (C2=C (N=C (OC[C@@]34N (C[C@H] (F) C3) CCC4) N=C2N1) N5CC6NC (C5) CC6) C7CCC7) C=8C9=C (C=C (O) C8) C=CC (F) =C9C#C
Molecular Formula
C35H37F2N7O3
Molecular Weight
641.72
Storage Conditions
-20°C
Notes
For research use only.

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