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BCR-ABL1-IN-2

CAT: 0804-HY-179247Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179247Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCR-ABL1-IN-2 (compound 8) is a potent BCR-ABL1 tyrosine kinase inhibitor. BCR-ABL1-IN-2 exhibits activity in Imatinib resistant K562/DOX cells with LC50 of 5.29 μM. BCR-ABL1-IN-2 shows no significant toxicity in nontumor cells. BCR-ABL1-IN-2 can be used for chronic myeloid leukemia research[1].
UNSPSC
12352005
Target
Bcr-Abl
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C=C1)CN2CCC(C3=CC=C(C=C3)N)CC2)NC4=CC=C(C(NC5=NC=CC(C6=CC=CN=C6)=N5)=C4)C
Molecular Formula
C35H35N7O
Molecular Weight
569.70
References & Citations
[1]Chowdhury MM, et al. Design, Synthesis, and Biological Evaluation of Efflux-Resistant Imatinib Derivatives. J Med Chem. 2025 Nov 13;68 (21) :22619-22632.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcr-Abl

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