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COX-2-IN-59

CAT: 0804-HY-179125Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179125Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 μM) . COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; COX
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(NC1=CC=C(OCC(N/N=C/C2=CC=C(OS(=O)(C)=O)C=C2)=O)C=C1)=O
Molecular Formula
C18H19N3O6S
Molecular Weight
405.42
References & Citations
[1]Kassem AF, et al. Dual Anticancer and COX-2 Inhibitory Activity of Tailored Paracetamol-Alkanesulfonate Conjugates: A Promising Therapeutic Approach. Arch Pharm (Weinheim) . 2025;358 (10) :e70125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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