STAT3/CAIX-IN-1

CAT: 0931-MF-0118002-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118002-01Size:10 mg
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CAS Number
3053583-60-8
Target
ROS|||STAT|||Carbonic Anhydrase|||Apoptosis|||Ferroptosis|||Bcl-2 Family|||Caspase
Related Pathways
Apoptosis|||Immunology/Inflammation|||Metabolism|||JAK/STAT signaling|||Proteases/Proteasome|||Stem Cells
Bioactivity
STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 ?M) and CAIX (IC50: 80.45 nM) . It induces ferroptosis by elevating reactive oxygen species (ROS) and lipid peroxides. This compound also inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 is applicable for research in triple-negative breast cancer (TNBC) .
Smiles
C(=C\1/C(=O)\C(=C\C2=CC=C(C(F)(F)F)C=C2)\CN(C(CCCC(NC=3SC(S(N)(=O)=O)=NN3)=O)=O)C1)\C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C28H23F6N5O5S2
Molecular Weight
687.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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