STAT3/CAIX-IN-1

CAT: 0931-T210790-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210790-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3053583-60-8

Target

ROS, STAT, Carbonic Anhydrase, Apoptosis, Ferroptosis, Bcl-2 Family, Caspase

Related Pathways

Apoptosis, Immunology/Inflammation, Metabolism, JAK/STAT signaling, Proteases/Proteasome, Stem Cells

Bioactivity

STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM) . It induces ferroptosis by elevating reactive oxygen species (ROS) and lipid peroxides. This compound also inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 is applicable for research in triple-negative breast cancer (TNBC) .

Smiles

C(=C\1/C(=O)\C(=C\C2=CC=C(C(F)(F)F)C=C2)\CN(C(CCCC(NC=3SC(S(N)(=O)=O)=NN3)=O)=O)C1)\C4=CC=C(C(F)(F)F)C=C4

Molecular Formula

C28H23F6N5O5S2

Molecular Weight

687.63

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19263302-01	STAT3/CAIX-IN-1
HY-146819	CAIX/CAXII-IN-1
34-009	CAIX Antibody [CBAD9-1]
GTR19272854-01	PDGFRA/CAIX/XII-IN-1
HY-179022	CAIX/CDK-2-IN-1
HY-175223	CAIX-IN-4
P10123	PET28a-CAIX
HY-170893	CAIX/CAXII-IN-4
HY-179034	CAIX/XII-IN-16
PVT19955	pET28a-CAIX Plasmid

STAT3/CAIX-IN-1

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