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HDAC-IN-94

CAT: 0804-HY-179019Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179019Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC50 = 4.5 nM) . HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10) . HDAC-IN-94 induces α-tubulin hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; HDAC; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
O=C(NCC1=CC=C(C(NO)=O)C=C1)/C=C/C2=CC(OC)=C(O)C=C2
Molecular Formula
C18H18N2O5
Molecular Weight
342.35
References & Citations
[1]Cursaro I, et al. New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells. Bioorg Chem. 2025 Oct 14;166:109085.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC5; HDAC6; HDAC8

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