PI3Kα-IN-28

CAT: 0804-HY-178984Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178984Size:1 Each
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Description
PI3Kα-IN-28 is an efficient dual targeted PI3K/BRD4 inhibitor. PI3Kα-IN-28 can inhibit the proliferation of various cells, such as KYSE180 (IC50 = 1.46 µM) and KYSE450 (IC50 = 0.57 µM) cells. PI3Kα-IN-28 can concentration dependently inhibit migration and colony formation, induce G0/G1 phase arrest, significantly inhibit DNA synthesis, and significantly increase the proportion of senescent cells. PI3Kα-IN-28 can inhibit the expression of p-AKT and c-Myc and activate the AMPK-p27 pathway. PI3Kα-IN-28 can be used for research on cancers such as esophageal cancer[1].
CAS Number
[3095278-75-1]
UNSPSC
12352005
Target
Akt; AMPK; c-Myc; DNA/RNA Synthesis; Epigenetic Reader Domain; PI3K
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CC1=C2C(C(OC3CCN(CC3)CC4CCN(CC4)C(C[C@@H]5N=C(C6=C(N7C5=NN=C7C)SC(C)=C6C)C8=CC=C(C=C8)Cl)=O)=CC(C9=CC(NS(C%10=CC=C(C=C%10F)F)(=O)=O)=C(N=C9)OC)=C2)=NC=N1
Molecular Formula
C51H51ClF2N10O5S2
Molecular Weight
1021.59
References & Citations
[1]Peng S, et al. Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms. J Med Chem. 2025 Oct 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; PI3Kα

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