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Nav1.2-IN-2

CAT: 0804-HY-178963-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178963-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nav1.2-IN-2 (Compound 1) is a Nav1.2 inhibitor with an IC₅₀ for inactivating Nav1.2 of 0.18 μM. Nav1.2-IN-2 can effectively suppress the amplitude and frequency of spontaneous synchronous calcium oscillations (SCOs), with IC₅₀ values of 0.38 μM and 0.88 μM respectively. Nav1.2-IN-2 inhibits Ca2+ influx induced by Veratridine , with an IC₅₀ of 1.89 μM. Nav1.2-IN-2 can be used for the study of diseases such as epilepsy[1].
CAS Number
7469-49-0
UNSPSC
12352005
Target
Calcium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.82
Solubility
DMSO : 4.17 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C)C(NC(OCCCC)=O)=C1)OCCCC
Molecular Formula
C17H26N2O4
Molecular Weight
322.40
References & Citations
[1]Xu J, et al. Aniline analogues as synchronized Ca2+ oscillation modulators: structure-activity relationship and mechanism. Eur J Med Chem. 2026 Jan 5;301:118267.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.2

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