GC-072

• Description :

  GC-072 is an orally active, 4-oxoquinolizine antibiotic that selectively inhibits bacterial DNA gyrase and Topo IV enzymes. GC-072 does not inhibit human topoisomerases I and II. GC-072 demonstrates strong antimicrobial activity against various bacterial strains, including Gram-positive, Gram-negative, and resistant bacteria. GC-072 also exhibits bactericidal activity against Burkholderia pseudomallei both extracellularly and intracellularly, leading to dose-dependent survival in mice exposed to lethal inhalational models of B. pseudomallei infection. GC-072 can be used for the research of melioidosis[1].

• Target :

  Antibiotic; Bacterial; DNA/RNA Synthesis; Topoisomerase

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  O=C(C1=CC(C2CC2)=C3C(C)=C(C4=C(F)C=C(N)C(F)=C4)C=CN3C1=O)O

• Molecular Formula :

  C20H16F2N2O3

• Molecular Weight :

  370.35

• References & Citations :

  [1]Shearer JD, et al. GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens. Antimicrob Agents Chemother. 2019;63 (12) :e00834-19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DNA gyrase; Topoisomerase

• CAS Number :

  [1371629-36-5]