ABT-072 (Standard)

• Description:

  ABT-072 (Standard) is the analytical standard of ABT-072 (HY-101634) . This product is intended for research and analytical applications. ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) [1][2][3].

• Target:

  HCV; Reference Standards

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Infection

• Smiles:

  CS (=O) (NC1=CC=C (/C=C/C2=CC (N (C (N3) =O) C=CC3=O) =CC (C (C) (C) C) =C2OC) C=C1) =O

• Molecular Formula:

  C24H27N3O5S

• Molecular Weight:

  469.55

• References & Citations:

  [1]Lawitz E, et al. A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1. J Hepatol. 2013;59 (1) :18-23.|[2]Shi Y, et al. Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method. J Pharm Sci. 2016;105 (9) :2886-2895.|[3]Randolph JT, et al. Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability. J Med Chem. 2018;61 (3) :1153-1163.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1132936-00-5