GC-7

CAT: 0804-HY-108314Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108314Size:1 Each
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Description
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
CAS Number
[150333-69-0]
UNSPSC
12352211
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gc-7.html
Solubility
10 mM in DMSO
Smiles
NC(NCCCCCCCN)=N
Molecular Formula
C8H20N4
Molecular Weight
172.27
References & Citations
[1]Bandino A, et al. Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients. Cell Oncol (Dordr) . 2014 Dec;37 (6) :387-98.|[2]Lou B, et al. N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells. Exp Cell Res. 2013 Oct 15;319 (17) :2708-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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