GC-7

• Description :

  GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

• UNSPSC :

  12352211

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gc-7.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC(NCCCCCCCN)=N

• Molecular Formula :

  C8H20N4

• Molecular Weight :

  172.27

• References & Citations :

  [1]Bandino A, et al. Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients. Cell Oncol (Dordr) . 2014 Dec;37 (6) :387-98.|[2]Lou B, et al. N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells. Exp Cell Res. 2013 Oct 15;319 (17) :2708-17.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [150333-69-0]