HYS-072

• Description :

  HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in the research of triple-negative breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Akt; Apoptosis; Autophagy; mTOR; PI3K

• Related Pathways :

  Apoptosis; Autophagy; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  CC1=CC=C(NC(NCCCCOC2=CC(O)=C3C(OC(C4=CC=CC=C4)=CC3=O)=C2)=O)C=C1

• Molecular Formula :

  C27H26N2O5

• Molecular Weight :

  458.51

• References & Citations :

  [1]Hou Y, et al. A novel chrysin derivative HYS-072 induces apoptosis and autophagy in Triple-negative breast cancer cells. Nat Prod Res. 2025 Feb 11:1-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported