HYS-072

• Description:

  HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in the research of triple-negative breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Akt; Apoptosis; Autophagy; mTOR; PI3K

• Related Pathways:

  Apoptosis; Autophagy; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  CC1=CC=C (NC (NCCCCOC2=CC (O) =C3C (OC (C4=CC=CC=C4) =CC3=O) =C2) =O) C=C1

• Molecular Formula:

  C27H26N2O5

• Molecular Weight:

  458.51

• References & Citations:

  [1]Hou Y, et al. A novel chrysin derivative HYS-072 induces apoptosis and autophagy in Triple-negative breast cancer cells. Nat Prod Res. 2025 Feb 11:1-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported