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Cot-IN-4

CAT: 0804-HY-178726Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178726Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid -stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases[1].
CAS Number
1984784-10-2
UNSPSC
12352005
Target
ERK; Interleukin Related; MAP3K; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
CC(CN1CCOCC1)NC2=CC=C3C(C=CC(N4C=NC5=C4C6=C(N=C5)C=NC(C7=CC=NC=C7)=C6)=C3)=N2
Molecular Formula
C30H28N8O
Molecular Weight
516.60
References & Citations
[1]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; IL-1; MAP3K8/COT/Tpl2; TNFRSF5/CD40

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