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Cot-IN-4

CAT: 0013-GTR19273917-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273917-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cot-IN-4 (compound 32) is a potent inhibitor of cancer Osaka thyroid (COT) kinase, with an IC50 value of 6 nM. It effectively inhibits the phosphorylation of ERK (IC50: 60 nM) and suppresses the release of TNFα (IC50: 60 nM) . Additionally, Cot-IN-4 reduces the production of the pro-inflammatory cytokine IL-1β in macrophages stimulated by uric acid (IC50: 0.2 μM) . This compound is applicable for research in inflammatory diseases.
CAS Number
1984784-10-2
Smiles
N1=CC=C (C=C1) C=2N=CC=3N=CC=4N=CN (C=5C=CC6=NC (=CC=C6C5) NC (C) CN7CCOCC7) C4C3C2
Molecular Formula
C30H28N8O
Molecular Weight
516.61
Storage Conditions
-20°C
Notes
For research use only.

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