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Cot inhibitor-3

CAT: 0804-HY-169153Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169153Size:1 Each
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Description
Cot inhibitor-3 (Compound 33) is a potent and selective cancer osaka thyroid (COT) kinase inhibitor, with an IC50 of 4 nM. Cot inhibitor-3 can be used to prevent inflammation-driven lameness[1].
CAS Number
1984784-12-4
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cot-inhibitor-3.html
Smiles
C[C@H](CN1CCOCC1)NC2=NC3=C(C=C2)C=C(C=C3)N4C5=C(N=C4)C=NC6=CN=C(C7=CC=NC=C7)C=C56
Molecular Formula
C30H28N8O
Molecular Weight
516.60
References & Citations
[1]Glatthar R, et, al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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