Cot inhibitor-1

CAT: 0804-HY-32015-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0804-HY-32015-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM[1].
CAS Number
[915365-57-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cot-inhibitor-1.html
Purity
98.45
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5
Molecular Formula
C27H27Cl2FN8
Molecular Weight
553.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3485-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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