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Nav1.7-IN-19

CAT: 0804-HY-178494-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178494-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1].
CAS Number
3097995-73-5
UNSPSC
12352005
Target
Potassium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
NC(C(C1CC1)NCCCC2=C(C=CC(Cl)=C2)OC3=C(C=C(C(F)=C3)S(=O)(NC4=NOC=C4)=O)Br)=O
Molecular Formula
C23H23BrClFN4O5S
Molecular Weight
601.87
References & Citations
[1]Wu R, et al. Design, synthesis, structure-activity relationship (SAR) and analgesic effect studies of novel arylsulfonamides as selective Nav1.7 inhibitors. Eur J Med Chem. 2025 Dec 5;299:118069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7

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