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Nav1.7-IN-13

CAT: 0804-HY-162347Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162347Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine -induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity[1].
CAS Number
2776235-57-3
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-7-in-13.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C/CN1C2=CC(Br)=CC=C2[C@@]([C@]3(C(OC)=O)OC(C=CC=C4)=C4C3)(O)C1=O
Molecular Formula
C23H22BrNO5
Molecular Weight
472.33
References & Citations
[1]Wang Y, et al. Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain. ACS Chem Neurosci. 2024 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7

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